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Tom Bäck Selected Research

Astatine-211

7/2022Estimating the risk for secondary cancer following targeted alpha therapy with astatine-211 intraperitoneal radioimmunotherapy.
1/2021Evaluation of therapeutic efficacy of 211At-labeled farletuzumab in an intraperitoneal mouse model of disseminated ovarian cancer.
1/2019Labeling of Anti-HER2 Nanobodies with Astatine-211: Optimization and the Effect of Different Coupling Reagents on Their in Vivo Behavior.
3/2016Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.
7/2015Automated astatination of biomolecules--a stepping stone towards multicenter clinical trials.
3/2015Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model.
8/2014Sequential radioimmunotherapy with 177Lu- and 211At-labeled monoclonal antibody BR96 in a syngeneic rat colon carcinoma model.
7/2014Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status.
10/2007Therapeutic efficacy of astatine-211-labeled trastuzumab on radioresistant SKOV-3 tumors in nude mice.

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Tom Bäck Research Topics

Disease

34Neoplasms (Cancer)
07/2022 - 05/2002
16Ovarian Neoplasms (Ovarian Cancer)
01/2021 - 11/2005
7Carcinoma (Carcinomatosis)
01/2017 - 10/2007
5Ascites
12/2017 - 11/2005
3Ovarian Epithelial Carcinoma
07/2022 - 01/2017
3Body Weight (Weight, Body)
12/2017 - 04/2013
3Residual Neoplasm
11/2015 - 11/2010
2Lymphoma (Lymphomas)
03/2015 - 11/2010
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
05/2013 - 07/2011
1Intestinal Perforation
01/2019
1Fatigue
01/2019
1Breast Neoplasms (Breast Cancer)
12/2017
1B-Cell Lymphoma (Lymphoma, B Cell)
03/2015
1Neoplasm Metastasis (Metastasis)
08/2014
1Neoplasm Micrometastasis
08/2013
1Leukemia
05/2013
1Weight Loss (Weight Reduction)
04/2013
1Disease Progression
03/2013
1Myeloid Leukemia (Leukemia, Myelocytic)
07/2011

Drug/Important Bio-Agent (IBA)

12Monoclonal AntibodiesIBA
01/2019 - 03/2003
9Astatine-211IBA
07/2022 - 10/2007
6211At-labeled monoclonal antibody MX35IBA
01/2021 - 08/2006
6AntibodiesIBA
01/2021 - 09/2008
6Radioisotopes (Radionuclides)IBA
01/2018 - 11/2010
4Biological ProductsIBA
07/2014 - 03/2003
3Proteins (Proteins, Gene)FDA Link
12/2017 - 11/2010
3Immunoconjugates (Immunoconjugate)IBA
03/2016 - 12/2005
3AstatineIBA
03/2016 - 12/2009
3procaine isothiocyanate (PRIT)IBA
03/2013 - 11/2010
2AntigensIBA
01/2019 - 01/2017
2Lysine (L-Lysine)FDA Link
12/2011 - 05/2002
1Thorium Dioxide (Thorotrast)IBA
07/2022
1Colloids (Colloid)IBA
07/2022
1Contrast MediaIBA
07/2022
1RadiopharmaceuticalsIBA
10/2021
1farletuzumabIBA
01/2021
1Rituximab (Mabthera)FDA Link
01/2021
1Indicators and Reagents (Reagents)IBA
01/2019
1Membrane Transport Proteins (Biological Pump)IBA
01/2017
1TinIBA
03/2016
1Neoplasm Antigens (Tumor Antigens)IBA
01/2015
1EpitopesIBA
01/2015
1HalogensIBA
08/2014
1Reducing AgentsIBA
08/2014
1BR96 monoclonal antibodyIBA
08/2014
1Lutetium-177IBA
08/2014
1Eosine Yellowish-(YS) (Eosin)IBA
08/2013
1Hematoxylin (Haematoxylon)IBA
08/2013
1Lewis Y antigenIBA
04/2013
1AvidinIBA
12/2011
1BismuthIBA
07/2011
1DOTA-biotin (90Y-DOTA-biotin)IBA
11/2010
1Biotin (Vitamin H)FDA Link
11/2010
1StreptavidinIBA
11/2010
1Bismuth-213IBA
11/2010
1Dihydrotachysterol (AT 10)IBA
10/2010
1Trastuzumab (Herceptin)FDA Link
10/2007
1SuspensionsIBA
03/2003

Therapy/Procedure

18Radioimmunotherapy
07/2022 - 11/2005
16Therapeutics
07/2022 - 05/2002
6Aftercare (After-Treatment)
12/2017 - 11/2005
5Drug Therapy (Chemotherapy)
07/2022 - 07/2009
2Intravenous Injections
01/2021 - 01/2017
2Catheters
01/2019 - 07/2009
1Transcutaneous Electric Nerve Stimulation (TENS)
08/2013
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
05/2013
1Hematopoietic Stem Cell Transplantation
05/2013
1Radiotherapy
10/2010